Yes and no.
Theoretically, if the base drop rate was a guaranteed 50% (50 drops per 100 kills) at 10 cryo per kill, a player with no reduction would make 500 cryo every 100 kills. A player with 6% reduction would make 440 with the same 100 kills. If the player with a reduction had a level 5 drone (10% cryo boost) they'd still only get 484 per 100 kills. Theoretically...
That being said, as you mentioned, the kill rate would be faster in a lower system where a reduction would be given. I can kill idunnohowmanyabunch of moli harvs in the same amount of time it takes to kill a hive harv, so it's not really drone vs reduction penalty, its time vs how many kills I can get. As mentioned earlier, I'd only make 484 per 100 kills with 6% - 20% reduction (theoretically) even with a level 5 drone, but if I can kill 200-300 mantis in the same amount of time the other guy can kill 100, I end up making more than them...unless it's like 500 kills x 10 cryo each vs 1 kill at 500 cryo each....obviously.
TL;DR
so it's not really drone vs reduction penalty, its time vs how many kills I can get. As mentioned earlier, I'd only make 484 per 100 kills with 6% -20% reduction (theoretically) even with a level 5 drone, but if I can kill 200-300 mantis in the same amount of time the other guy can kill 100, I end up making more than them...unless it's like 500 kills x 10 cryo each vs 1 kill x 500 cryo
-SoaL